Quetiapine Fumarate

Modify Date: 2024-01-02 18:43:56

Quetiapine Fumarate Structure
Quetiapine Fumarate structure
 Common Name Quetiapine Fumarate
CAS Number 111974-72-2 Molecular Weight 441.54
Density N/A Boiling Point 556.5ºC at 760 mmHg
Molecular Formula C23H27N3O4S Melting Point 174-176°C
MSDS Chinese USA Flash Point 290.4ºC
Symbol GHS07 GHS09
GHS07, GHS09		 Signal Word Warning

 Use of Quetiapine Fumarate


Quetiapine fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.IC50 value: Target: 5-HT ReceptorQuetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

 Names

Name quetiapine fumarate
Synonym More Synonyms

 Quetiapine Fumarate Biological Activity

Description Quetiapine fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.IC50 value: Target: 5-HT ReceptorQuetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.
Related Catalog
References

[1]. Sheehan DV, Locklear J, Sveds?ter H, Datto C. Long-term functioning and sleep quality in patients with major depressive disorder treated with extended-release quetiapine fumarate. Int Clin Psychopharmacol. 2012 Sep;27(5):239-48.

[2]. Endicott J, Sveds?ter H, Locklear JC. Effects of once-daily extended release quetiapine fumarate on patient-reported outcomes in patients with generalized anxiety disorder. Neuropsychiatr Dis Treat. 2012;8:301-311.

[3]. Lee JG, Lee JI, Kim YT, Kim CE, Kim CY, Yoon JS, Yoo SY, Kim YH. Safety of quetiapine fumarate extended release in the treatment of Korean patients with acute schizophrenia. Hum Psychopharmacol. 2012 Jul;27(4):403-10. doi: 10.1002/hup.2241.

[4]. Thase ME, Demyttenaere K, Earley WR, Gustafsson U, Udd M, Eriksson H. Extended release quetiapine fumarate in major depressive disorder: analysis in patients with anxious depression. Depress Anxiety. 2012 Jul;29(7):574-86. doi: 10.1002/da.21970.

[5]. Katila H, Mezhebovsky I, Mulroy A, Berggren L, Eriksson H, Earley W, Datto C. Randomized, Double-Blind Study of the Efficacy and Tolerability of Extended Release Quetiapine Fumarate (Quetiapine XR) Monotherapy in Elderly Patients With Major Depressive Di

 Chemical & Physical Properties

Boiling Point 556.5ºC at 760 mmHg
Melting Point 174-176°C
Molecular Formula C23H27N3O4S
Molecular Weight 441.54
Flash Point 290.4ºC
PSA 221.80000
LogP 4.04660
Vapour Pressure 3.22E-13mmHg at 25°C
Storage condition -20°C Freezer

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H400
Precautionary Statements P273
Hazard Codes T,F
Risk Phrases R45:May cause cancer. R10:Flammable.
Safety Phrases S53-S45
RIDADR UN 3295 3/PG 3
WGK Germany 3
RTECS PC1075000
Packaging Group III
Hazard Class 3
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

MFCD03423782
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
Quetiapine Hemifumarate
2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy}ethanol 2-butenedioate (2:1)
Quetiapine fumarate
Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-, 2-butenedioate (2:1) (salt)
Quetiapine hemifumarate salt
Quetiapine (fumarate)
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Related Compounds: More...
Ethyl Quetiapine FuMarate Salt
1011758-06-7
Quetiapine-d8 (fumarate)
1185247-12-4
Quetiapine D4 fumarate
1287376-15-1
Quetiapine D4 hemifumarate
1217310-65-0
Quetiapine Sulfoxide
329216-63-9
Quetiapine Impurity-N
1800291-86-4
Quetiapine
111974-69-7
2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy}ethyl [4-(dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]acetate
1798840-31-9
Quetiapine N-oxide
1076199-40-0
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
N-Acetyl-3-(5-isoxazolyl)-DL-alanine
119377-31-0
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
849349-65-1
Chemsrc provides Quetiapine Fumarate(CAS#:111974-72-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Quetiapine Fumarate are included as well.>> amp version: Quetiapine Fumarate

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