Triethylene glycol dimethyl ether

Modify Date: 2024-01-02 16:25:43

Triethylene glycol dimethyl ether Structure
Triethylene glycol dimethyl ether structure
Common Name Triethylene glycol dimethyl ether
CAS Number 112-49-2 Molecular Weight 178.22600
Density 0.986 g/mL at 25 °C(lit.) Boiling Point 216 °C(lit.)
Molecular Formula C8H18O4 Melting Point −45 °C(lit.)
MSDS Chinese USA Flash Point 231 °F
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

 Names

Name triglyme
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.986 g/mL at 25 °C(lit.)
Boiling Point 216 °C(lit.)
Melting Point −45 °C(lit.)
Molecular Formula C8H18O4
Molecular Weight 178.22600
Flash Point 231 °F
Exact Mass 178.12100
PSA 36.92000
LogP 0.31240
Vapour density >4.7 (vs air)
Index of Refraction n20/D 1.423(lit.)
Storage condition Refrigerator

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XF0665000
CHEMICAL NAME :
2,5,8,11-Tetraoxadodecane
CAS REGISTRY NUMBER :
112-49-2
BEILSTEIN REFERENCE NO. :
1700630
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C8-H18-O4
MOLECULAR WEIGHT :
178.26
WISWESSER LINE NOTATION :
1O2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB86-103215
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 31,53A,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB86-103215
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
28 gm/kg
SEX/DURATION :
female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,29,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3500 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-181657
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3500 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-181657
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3325 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 19,238,1992 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0064 No. of Facilities: 27 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 270 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H319-H360Df
Supplemental HS May form explosive peroxides.
Precautionary Statements P201-P280-P305 + P351 + P338-P308 + P313-P337 + P313
Hazard Codes T:Toxic;
Risk Phrases R19;R61;R62
Safety Phrases S53-S45
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS XF0665000
HS Code 2942000000

 Synthetic Route

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Triethylene glycol dimethyl ether Structure

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CAS#:112-49-2

Detail
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CAS#:112-49-2

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Literature: Angewandte Chemie, , vol. 87, # 22 p. 812 - 813

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CAS#:112-49-2

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CAS#:112-49-2

Literature: Industrial and Engineering Chemistry, , vol. 29, p. 548 Chem. Zentralbl., , vol. 109, # I p. 4534

 Customs

HS Code 2901100000
Summary 2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

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FETAX (Frog Embryo Teratogenesis Assay-Xenopus) is a 96-h whole-embryo developmental toxicity screening assay that can be used in ecotoxicology and in detecting mammalian developmental toxicants when ...

Radical Cationic Pathway for the Decay of Ionized Glyme Molecules in Liquid Solution.

J. Phys. Chem. B 119 , 14472-8, (2015)

Chemical stability of primary radical cations (RCs) generated in irradiated matter determines substantially the radiation resistance of organic materials. Transformations of the RCs of the glyme molec...

Relative potency of four ethylene glycol ethers for induction of paw malformations in the CD-1 mouse.

Teratology 35(3) , 321-8, (1987)

Time-mated CD-1 mice were orally dosed on gestation day 11 (plug = 0) with distilled water (control) or one of four glycol ethers at a dose of 4 mmol/kg: ethylene glycol monomethyl ether (EGME, 304 mg...

 Synonyms

Dimethyltriglycol
EINECS 203-977-3
Triethylene glycol dimethyl ether
MFCD00008504
1,2-Bis(2-methoxyethoxy)ethane,Dimethyltriglycol,Triglyme
2,5,8,11-Tetraoxadodecane
1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane
1,2-Bis(2-methoxyethoxy)ethane
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