2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

Modify Date: 2024-01-02 16:05:15

2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol structure	Common Name	2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
	CAS Number	112-60-7	Molecular Weight	194.225
	Density	1.1±0.1 g/cm3	Boiling Point	328.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₈O₅	Melting Point	-5.6 °C(lit.)
	MSDS	Chinese USA	Flash Point	176.7±0.0 °C

Use of 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Name	tetraethylene glycol
Synonym	More Synonyms

Description	PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.1±0.1 g/cm3
Boiling Point	328.0±0.0 °C at 760 mmHg
Melting Point	-5.6 °C(lit.)
Molecular Formula	C₈H₁₈O₅
Molecular Weight	194.225
Flash Point	176.7±0.0 °C
Exact Mass	194.115417
PSA	68.15000
LogP	-2.23
Vapour density	6.7 (vs air)
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.455
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility	soluble

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XC2100000

CHEMICAL NAME :: Tetraethylene glycol

CAS REGISTRY NUMBER :: 112-60-7

BEILSTEIN REFERENCE NO. :: 1634320

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H18-O5

MOLECULAR WEIGHT :: 194.26

WISWESSER LINE NOTATION :: Q2O2O2O2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28900 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0987-0693 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84662 No. of Facilities: 206 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 1685 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84662 No. of Facilities: 3704 (estimated) No. of Industries: 40 No. of Occupations: 44 No. of Employees: 55282 (estimated) No. of Female Employees: 1585 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes	C
Risk Phrases	36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	XC2100000
HS Code	2942000000

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HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol

2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

Tetra(ethylene glycol)

2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol

MFCD00002879

Tetraglycol

Ethyl acetate

Tetraethylene glycol

2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol

EINECS 203-989-9

Bis[2-(2-hydroxyethoxy)ethyl] ether

Bis[2-(2-hydroxyethoxy)ethyl]ether

tetraethylene glycol-

tetraethyleneglycol

Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-

PEG-4

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China
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
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China
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China
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China
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Use of 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

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