Tebufelone

Modify Date: 2024-01-15 08:17:16

Tebufelone Structure
Tebufelone structure
Common Name Tebufelone
CAS Number 112018-00-5 Molecular Weight 300.43500
Density 0.992g/cm3 Boiling Point 383.6ºC at 760mmHg
Molecular Formula C20H28O2 Melting Point N/A
MSDS N/A Flash Point 163.8ºC

 Use of Tebufelone


Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].

 Names

Name 1-(3,5-ditert-butyl-4-hydroxyphenyl)hex-5-yn-1-one
Synonym More Synonyms

 Tebufelone Biological Activity

Description Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].
Related Catalog
Target

COX-2

5-LO

References

[1]. S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63.  

[2]. Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206.  

 Chemical & Physical Properties

Density 0.992g/cm3
Boiling Point 383.6ºC at 760mmHg
Molecular Formula C20H28O2
Molecular Weight 300.43500
Flash Point 163.8ºC
Exact Mass 300.20900
PSA 37.30000
LogP 4.97340
Vapour Pressure 1.97E-06mmHg at 25°C
Index of Refraction 1.515

 Synonyms

4-(5'-hexynoyl)-2,6-di-tert-butylphenol
Tebufelone
Tebufelonum [INN-Latin]
5-Hexyn-1-one,1-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)
Tebufelona
Tebufelone [USAN:INN]
Tebufelonum
Tebufelona [INN-Spanish]
4-(5'-hexynoyl)-2,6-di-t-butylphenol