SMPT

Modify Date: 2024-01-10 17:14:29

SMPT Structure
SMPT structure
Common Name SMPT
CAS Number 112241-19-7 Molecular Weight 388.46100
Density 1.43g/cm3 Boiling Point 547ºC at 760mmHg
Molecular Formula C18H16N2O4S2 Melting Point N/A
MSDS USA Flash Point 284.6ºC

 Use of SMPT


SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name (2,5-dioxopyrrolidin-1-yl) 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate
Synonym More Synonyms

 SMPT Biological Activity

Description SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Density 1.43g/cm3
Boiling Point 547ºC at 760mmHg
Molecular Formula C18H16N2O4S2
Molecular Weight 388.46100
Flash Point 284.6ºC
Exact Mass 388.05500
PSA 127.17000
LogP 3.74180
Vapour Pressure 5.11E-12mmHg at 25°C
Index of Refraction 1.675

 Synonyms

1-({4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoyl}oxy)pyrrolidine-2,5-dione
SMPT
2,5-Pyrrolidinedione,1-((4-(1-(2-pyridinyldithio)ethyl)benzoyl)oxy)