Antide

Modify Date: 2024-01-03 00:48:05

Antide structure	Common Name	Antide
	CAS Number	112568-12-4	Molecular Weight	1591.293
	Density	1.3±0.1 g/cm3	Boiling Point	1798.0±65.0 °C at 760 mmHg
	Molecular Formula	C₈₂H₁₀₈ClN₁₇O₁₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	1041.2±34.3 °C
	Symbol	GHS08	Signal Word	Danger

Use of Antide

Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.

Name	Antide
Synonym	More Synonyms

Description	Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Cancer
In Vivo	Antide (subcutaneously; 1, 3, 6, 10 and 15 mg/kg; once or on 5 consecutive days) can induce a long-term chemical castration in adult male rats and cynomolgus monkeys[1]. Animal Model: Cynomolgus monkey and rat[1] Dosage: 1, 3, 6, 10 and 15 mg/kg Administration: Subcutaneous, once or on 5 consecutive days Result: Had a dose-dependent inhibitory effect on serum concentration of LH (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles. Achieved long-lasting castration-like effects at concentrations between 6 (less than or equal to 8 weeks) and 15 mg/kg (greater than 8 weeks) in the rat. Induced a prolonged inhibitory effect only at 15 mg/kg and the duration was only 2-3 weeks in the cynomolgus monkey.
References	[1]. U F Habenicht, et al. Effect of the new potent LHRH antagonist antide. J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):937-42.

Density	1.3±0.1 g/cm3
Boiling Point	1798.0±65.0 °C at 760 mmHg
Molecular Formula	C₈₂H₁₀₈ClN₁₇O₁₄
Molecular Weight	1591.293
Flash Point	1041.2±34.3 °C
Exact Mass	1589.795044
PSA	454.43000
LogP	4.91
Appearance of Characters	Solid \| White to off-white
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.593
Storage condition	−20°C

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R60
Safety Phrases	S53-S22-S36/37/39-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AY2961700

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Detail

Literature: Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4270 - 4278

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AC-(D-NAL)-(D-P-CL-PHE)-(D-PAL)-SER-LYS(NICOTINOYL)-[D-LYS(NICOTINOYL)]-LEU-LYS(ISOPROPYL)-PRO-[D-ALA]-NH2

Iturelix

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lyl

AC-DNAL-D: P-CLPHE-DPAL-SER-LYS: NICOTINOYL-DLYS: NICOTINOYL-LEU-LYS: ISOPROPYL-PRO-DALA-NH2