PQCA
Modify Date: 2024-01-03 14:44:29
PQCA structure
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Common Name | PQCA | ||
|---|---|---|---|---|
| CAS Number | 1144504-35-7 | Molecular Weight | 388.41900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PQCAPQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively, and is inactive for other muscarinic receptors. PQCA improves cognitive performance and cerebral blood flow in rat, cynomolgus macaque, and rhesus macaque. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2]. |
| Name | pqca |
|---|---|
| Synonym | More Synonyms |
| Description | PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively, and is inactive for other muscarinic receptors. PQCA improves cognitive performance and cerebral blood flow in rat, cynomolgus macaque, and rhesus macaque. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 49 nM (Rhesus M1 receptor) and 135 nM (Human M1 receptor)[1] |
| In Vivo | PQCA (3-30 mg/kg; Oral administration; single- or pair-housed male rhesus monkeys) treatment attenuates the scopolamine deficits in PAL and CPT tasks. Blockade of muscarinic signaling by scopolamine produces significant impairments in both tasks[1]. Animal Model: Ten single- or pair-housed male rhesus monkeys (6-10 years old; 5.2-10.5 kg) with scopolamine[1] Dosage: 3 mg/kg, 10 mg/kg, or 30 mg/kg Administration: Oral administration Result: Attenuated the scopolamine deficits in paired-associates learning (PAL) and the continuous-performance task (CPT). |
| References |
| Molecular Formula | C22H20N4O3 |
|---|---|
| Molecular Weight | 388.41900 |
| Exact Mass | 388.15400 |
| PSA | 98.70000 |
| LogP | 2.38798 |
| 1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid |
| 1-[(4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl]-4-oxo-4H-quinolizine-3-carboxylate |
| 1-(4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl-4-oxo-4 H-quinolizine-3-carboxylic acid |
| 1-[(4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl]-4-oxo-4H-quinolizine-3-carboxylic acid |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: PQCA
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: PQCA
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: PQCA
- Price: $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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