J-147
Modify Date: 2024-01-02 14:08:50
J-147 structure
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Common Name | J-147 | ||
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| CAS Number | 1146963-51-0 | Molecular Weight | 350.335 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 412.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H17F3N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 203.5±31.5 °C | |
Use of J-147J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in vitro assay [1]Target: J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 – 0.115 μM) when applied to cell exposed to the mitochondrial neurotoxin, iodoacetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. In the preclinical in vitro development assays, the EC50 value for J-147-induced cell survival is 25 nM. J-147 was metabolically unstable (highly metabolized) with only 12% of parent remaining after incubation with rat microsomes (phase 1 metabolism). |
| Name | j 147 |
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| Synonym | More Synonyms |
| Description | J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in vitro assay [1]Target: J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 – 0.115 μM) when applied to cell exposed to the mitochondrial neurotoxin, iodoacetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. In the preclinical in vitro development assays, the EC50 value for J-147-induced cell survival is 25 nM. J-147 was metabolically unstable (highly metabolized) with only 12% of parent remaining after incubation with rat microsomes (phase 1 metabolism). |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 412.8±55.0 °C at 760 mmHg |
| Molecular Formula | C18H17F3N2O2 |
| Molecular Weight | 350.335 |
| Flash Point | 203.5±31.5 °C |
| Exact Mass | 350.124207 |
| PSA | 41.90000 |
| LogP | 5.61 |
| Appearance of Characters | light yellow solid |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.515 |
| Storage condition | -20℃ |
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~85%
J-147 CAS#:1146963-51-0 |
| Literature: Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 2 p. 524 - 527 |
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~%
J-147 CAS#:1146963-51-0 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 2 p. 524 - 527 |
| Precursor 3 | |
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| DownStream 0 | |
| N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide |
| Acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-[(1E)-(3-methoxyphenyl)methylene]hydrazide |
| J-147 |