Mupirocin calcium hydrate

Modify Date: 2024-01-03 17:13:31

Mupirocin calcium hydrate Structure
Mupirocin calcium hydrate structure
Common Name Mupirocin calcium hydrate
CAS Number 115074-43-6 Molecular Weight 1075.34000
Density N/A Boiling Point 672.3ºC at 760 mmHg
Molecular Formula C26H44O9.1/2Ca.H2O Melting Point N/A
MSDS N/A Flash Point 216.5ºC

 Use of Mupirocin calcium hydrate


Mupirocin calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2].

 Names

Name mupirocin calcium, reference spectrum ep standard
Synonym More Synonyms

 Mupirocin calcium hydrate Biological Activity

Description Mupirocin calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2].
Related Catalog
In Vitro Mupirocin Calcium Salt shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin Calcium Salt is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum[1].
In Vivo Mupirocin Calcium Salt is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1].
References

[1]. Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27(4):495-8.

[2]. Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70.

 Chemical & Physical Properties

Boiling Point 672.3ºC at 760 mmHg
Molecular Formula C26H44O9.1/2Ca.H2O
Molecular Weight 1075.34000
Flash Point 216.5ºC
Exact Mass 1074.57000
PSA 288.56000
LogP 4.90220
Vapour Pressure 5.91E-21mmHg at 25°C
Storage condition -20℃
Water Solubility Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride.

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Mupirocin calcium dihydrate
Unii-rg38I2p540
MupirocinCalcium
mupirocin calcium hydrate
Calcium mupirocin dihydrate
Mupirocin Calcium Salt
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