IOX4
Modify Date: 2024-01-09 17:31:23
IOX4 structure
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Common Name | IOX4 | ||
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| CAS Number | 1154097-71-8 | Molecular Weight | 328.326 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 502.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H16N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 257.5±32.9 °C | |
Use of IOX4IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2[1]. |
| Name | 2-Methyl-2-propanyl 6-[5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl]nicotinate |
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| Synonym | More Synonyms |
| Description | IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2[1]. |
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| Related Catalog | |
| Target |
IC50: 1.6 nM (PHD2)[1] |
| In Vitro | IOX4 (1-100 μM; 5 hours) determines the EC50s for HIF1α induction are 114 μM, 86 μM and 49.5 μM in MCF-7, Hep3B and U2OS, respectively[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.2±60.0 °C at 760 mmHg |
| Molecular Formula | C15H16N6O3 |
| Molecular Weight | 328.326 |
| Flash Point | 257.5±32.9 °C |
| Exact Mass | 328.128387 |
| LogP | 0.73 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.673 |
| 2-Methyl-2-propanyl 6-[5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl]nicotinate |
| 3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester |