[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea
Modify Date: 2024-01-11 12:06:39
![[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea Structure](https://image.chemsrc.com/caspic/356/1155877-97-6.png)
[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea structure
|
Common Name | [4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea | ||
|---|---|---|---|---|
| CAS Number | 1155877-97-6 | Molecular Weight | 366.84 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of [4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]ureaD159687 is a selective PDE4D inhibitor[1]. |
| Name | [4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea |
|---|---|
| Synonym | More Synonyms |
| Description | D159687 is a selective PDE4D inhibitor[1]. |
|---|---|
| Related Catalog | |
| Target |
PDE4D[1] |
| In Vitro | D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1]. D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 1 μM Incubation Time: 0, 1, 3, 6, 12, 24 hours Result: Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 0.01 μM, 0.1 μM, 1 μM Incubation Time: 6 hours Result: CREB phosphorylation was optimal at 1 μM. |
| In Vivo | D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: Female Cynomolgus macaques (4–6 year old) [2] Dosage: 0.05, 0.5, 5 mg/kg Administration: Oral daily for a week Result: A potential recruitment or enhancement of synaptic function with increased task difficulty. |
| References |
| Molecular Formula | C21H19ClN2O2 |
|---|---|
| Molecular Weight | 366.84 |
| Exact Mass | 366.11400 |
| PSA | 65.34000 |
| LogP | 5.68380 |
| Storage condition | 2-8℃ |
| HS Code | 2924299090 |
|---|
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Urea,N-(4-((3'-chloro-6-methoxy(1,1'-biphenyl)-3-yl)methyl)phenyl) |
| UNII-4T436CO8BT |
| 1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea |
| [4-(3'-Chloro-6-methoxy-biphenyl-3-ylmethyl)-phenyl]-urea |