Edrophonium chloride

Modify Date: 2024-01-02 18:43:29

Edrophonium chloride Structure
Edrophonium chloride structure
Common Name Edrophonium chloride
CAS Number 116-38-1 Molecular Weight 201.693
Density 1.395 g/mL at 25 °C(lit.) Boiling Point 130 °C20 mm Hg(lit.)
Molecular Formula C10H16ClNO Melting Point 162-163°C
MSDS N/A Flash Point >230 °F

 Use of Edrophonium chloride


Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

 Names

Name edrophonium chloride
Synonym More Synonyms

 Edrophonium chloride Biological Activity

Description Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
Related Catalog

 Chemical & Physical Properties

Density 1.395 g/mL at 25 °C(lit.)
Boiling Point 130 °C20 mm Hg(lit.)
Melting Point 162-163°C
Molecular Formula C10H16ClNO
Molecular Weight 201.693
Flash Point >230 °F
Exact Mass 201.092041
PSA 20.23000
Index of Refraction n20/D 1.486(lit.)
Storage condition 2-8°C
Water Solubility reacts

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BQ5870000
CHEMICAL NAME :
Ammonium, ethyl(m-hydroxyphenyl)dimethyl-, chloride
CAS REGISTRY NUMBER :
116-38-1
LAST UPDATED :
199504
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H16-N-O.Cl
MOLECULAR WEIGHT :
201.72
WISWESSER LINE NOTATION :
QR CK2&1&1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,327,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,121,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,185,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5548 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8250 (estimated) No. of Female Employees: 7491 (estimated)

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS BQ5870000
HS Code 2923900090

 Synthetic Route

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Edrophonium chloride Structure

Edrophonium chloride

CAS#:116-38-1

Literature: DE837098 , ; DRP/DRBP Org.Chem.

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Edrophonium chloride Structure

Edrophonium chloride

CAS#:116-38-1

Literature: DE837098 , ; DRP/DRBP Org.Chem.

 Customs

HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

edrophonium chloride
MFCD00055064
EINECS 204-138-4
Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride (1:1)
N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium chloride
Ethyl(m-hydroxyphenyl)dimethylammonium chloride
Tensilon
N-Ethyl-3-hydroxy-N,N-dimethylanilinium chloride
ethyl-(3-hydroxyphenyl)-dimethylazanium,chloride
Edrophonium (chloride)
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