MCB-613

Modify Date: 2024-01-02 20:42:08

MCB-613 structure	Common Name	MCB-613
	CAS Number	1162656-22-5	Molecular Weight	304.386
	Density	1.159±0.06 g/cm3	Boiling Point	510.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	257.9±36.5 °C

Use of MCB-613

MCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator.Target: SRCin vitro: MCB-613 exerts the greatest activation of SRC-1 in the primary screen, is confirmed to be a strong activator of all three SRCs. MCB-613 can super-stimulate SRCs' transcriptional activity. MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1]in vivo: In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1]

Name	4-ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
Synonym	More Synonyms

Description	MCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator.Target: SRCin vitro: MCB-613 exerts the greatest activation of SRC-1 in the primary screen, is confirmed to be a strong activator of all three SRCs. MCB-613 can super-stimulate SRCs' transcriptional activity. MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1]in vivo: In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1]
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Cancer
References	[1]. Wang L, et al. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10;28(2):240-52.

Density	1.159±0.06 g/cm3
Boiling Point	510.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀N₂O
Molecular Weight	304.386
Flash Point	257.9±36.5 °C
Exact Mass	304.157562
PSA	42.85000
LogP	4.55
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.640
Storage condition	-20℃
Water Solubility	Practically insoluble (0.061 g/L) (25 ºC)