BRL 15572 hydrochloride
Modify Date: 2024-01-20 13:14:32
BRL 15572 hydrochloride structure
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Common Name | BRL 15572 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1173022-77-9 | Molecular Weight | 443.409 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H28Cl2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRL 15572 hydrochlorideBRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1]. |
| Name | TCMDC-123456 |
|---|---|
| Synonym | More Synonyms |
| Description | BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1]. |
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| Related Catalog | |
| Target |
5-HT1D Receptor |
| In Vitro | BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells[1]. BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors[1]. |
| In Vivo | BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2]. BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3]. |
| References |
| Molecular Formula | C25H28Cl2N2O |
|---|---|
| Molecular Weight | 443.409 |
| Exact Mass | 442.157867 |
| 1-Piperazineethanol, 4-(3-chlorophenyl)-α-(diphenylmethyl)-, hydrochloride (1:1) |
| 3-[4-(3-Chlorophenyl)-1-piperazinyl]-1,1-diphenyl-2-propanol hydrochloride (1:1) |
| TCMDC-123456 |
| 3-[4-(3-Chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride (1:1) |
| 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride |