SMANT hydrochloride
Modify Date: 2024-01-29 13:48:57
SMANT hydrochloride structure
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Common Name | SMANT hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1177600-74-6 | Molecular Weight | 375.73200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H24BrClN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | ||
Use of SMANT hydrochlorideSMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1]. |
| Name | N-(4-Bromophenyl)-3-(3,5-dimethyl-1-piperidinyl)propanamide hydro chloride (1:1) |
|---|
| Description | SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1]. |
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| Related Catalog | |
| Target |
Smo, SmoM2[1] |
| In Vitro | SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC50: 1.1 μM)[1]. SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay[1]. SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1+/− neonates) induced by Shh[1]. |
| References |
| Molecular Formula | C16H24BrClN2O |
|---|---|
| Molecular Weight | 375.73200 |
| Exact Mass | 374.07600 |
| PSA | 32.34000 |
| LogP | 4.56850 |
| Symbol |
GHS09 |
|---|---|
| Hazard Statements | H411 |
| Precautionary Statements | P273-P391-P501 |
| RIDADR | UN 3077 9 / PGIII |