Enterostatin human
Modify Date: 2024-01-02 11:22:11
Enterostatin human structure
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Common Name | Enterostatin human | ||
|---|---|---|---|---|
| CAS Number | 117830-79-2 | Molecular Weight | 496.56100 | |
| Density | 1.54g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H36N8O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Enterostatin humanEnterostatin, human, mouse, rat is a pentapeptide that reduces fat intake. |
| Name | (2S)-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
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| Synonym | More Synonyms |
| Description | Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%)[1]. |
| In Vivo | Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion[2]. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice[3]. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake[4]. |
| References |
| Density | 1.54g/cm3 |
|---|---|
| Molecular Formula | C21H36N8O6 |
| Molecular Weight | 496.56100 |
| Exact Mass | 496.27600 |
| PSA | 224.04000 |
| Index of Refraction | 1.681 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
|---|
| CLAP |
| H-Ala-Pro-Gly-Pro-Arg-OH |
| Enterostatin human |
| APGPR |
| APGPR Enterostatin |
| Ala-pro-gly-pro-arg |
| Procolipase activation peptide |
| ALA-PRO-GLY-PRO-ARG |
| Enterostatin, human, mouse, rat |
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