BW A868C

Modify Date: 2024-01-14 07:04:16

BW A868C Structure
BW A868C structure
Common Name BW A868C
CAS Number 118675-50-6 Molecular Weight 459.578
Density 1.2±0.1 g/cm3 Boiling Point 638.1±65.0 °C at 760 mmHg
Molecular Formula C25H37N3O5 Melting Point N/A
MSDS Chinese USA Flash Point 339.7±34.3 °C

 Use of BW A868C


BW A868C, a hydantoin compound, is a BW245C structural analogue. BW A868C is a selective and potent competitive prostaglandin D2 (PGD2) antagonist. BW A868C has no effect on other prostaglandin receptors (IP, EP1, EP2, TP and FP)[1].

 Names

Name 7-[1-benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxoimidazolidin-4-yl]heptanoic acid
Synonym More Synonyms

 BW A868C Biological Activity

Description BW A868C, a hydantoin compound, is a BW245C structural analogue. BW A868C is a selective and potent competitive prostaglandin D2 (PGD2) antagonist. BW A868C has no effect on other prostaglandin receptors (IP, EP1, EP2, TP and FP)[1].
Related Catalog
Target

PGD2

In Vitro BW A868C antagonizes prosaglandin D2 and BW245C-induced activation of human platelet adenylate cyclase[1].
References

[1]. H Giles, et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br J Pharmacol. 1989 Feb;96(2):291-300.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 638.1±65.0 °C at 760 mmHg
Molecular Formula C25H37N3O5
Molecular Weight 459.578
Flash Point 339.7±34.3 °C
Exact Mass 459.273315
PSA 110.18000
LogP 3.31
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.593

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles28

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Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2.

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 Synonyms

4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-
BW A868C
3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid
7-{1-Benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-4-imidazolidinyl}heptanoic acid
7-{1-Benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxoimidazolidin-4-yl}heptanoic acid
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