BMS-764459

Modify Date: 2024-01-02 16:42:14

BMS-764459 Structure
BMS-764459 structure
Common Name BMS-764459
CAS Number 1188407-45-5 Molecular Weight 405.39900
Density N/A Boiling Point N/A
Molecular Formula C19H21F2N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BMS-764459


BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer[1][2].

 Names

Name 4-[(1S)-1-Cyclopropyl-2-methoxyethyl]-6-{[6-(difluoromethoxy)-2,5 -dimethyl-3-pyridinyl]amino}-5-oxo-4,5-dihydro-2-pyrazinecarbonit rile

 BMS-764459 Biological Activity

Description BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer[1][2].
Related Catalog
Target

CRF1[1], CYP1A1[2]

References

[1]. David K. Leahy, et al. Development of an Efficient Synthesis of Two CRF Antagonists for the Treatment of Neurological Disorders. Org. Process Res. Dev. 2010, 14, 5, 1221-1228.

[2]. Simic D, et al. MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459. Toxicology. 2013 Sep 15;311(3):169-77.  

 Chemical & Physical Properties

Molecular Formula C19H21F2N5O3
Molecular Weight 405.39900
Exact Mass 405.16100
PSA 105.29000
LogP 2.49118