Flavoxate-d4 hydrochloride

Modify Date: 2024-01-18 18:08:18

Flavoxate-d4 hydrochloride Structure
Flavoxate-d4 hydrochloride structure
Common Name Flavoxate-d4 hydrochloride
CAS Number 1189678-43-0 Molecular Weight 431.94500
Density N/A Boiling Point N/A
Molecular Formula C24H22ClD4NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Flavoxate-d4 hydrochloride


Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate Hydrochloride is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic[1][2].

 Names

Name (1,1,2,2-tetradeuterio-2-piperidin-1-ylethyl) 3-methyl-4-oxo-2-phenylchromene-8-carboxylate,hydrochloride
Synonym More Synonyms

 Flavoxate-d4 hydrochloride Biological Activity

Description Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate Hydrochloride is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Dansette, P.M., M. Jaoen, and C. Pons, HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp Toxicol Pathol, 2000. 52(2): p. 145-8.

[3]. Kimura, Y., et al., Mechanisms of the suppression of the bladder activity by flavoxate. Int J Urol, 1996. 3(3): p. 218-27.

[4]. Oka, M., et al., Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res, 1996. 727(1-2): p. 91-8.

 Chemical & Physical Properties

Molecular Formula C24H22ClD4NO4
Molecular Weight 431.94500
Exact Mass 431.18000
PSA 59.75000
LogP 5.15100

 Synonyms

Bladderon-d4
Flavoxate-d4 Hydrochloride
DW 61-d4
Rec 7/0040-d4