Molindone-d8

Modify Date: 2024-01-08 17:59:19

Molindone-d8 Structure
Molindone-d8 structure
Common Name Molindone-d8
CAS Number 1189805-13-7 Molecular Weight 284.42300
Density N/A Boiling Point N/A
Molecular Formula C16H16D8N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Molindone-d8


Molindone-d8 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].

 Names

Name Molindone-d8
Synonym More Synonyms

 Molindone-d8 Biological Activity

Description Molindone-d8 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Yu C, et al. In vitro pharmacological characterization of SPN-810M (molindone). J Exp Pharmacol. 2018;10:65-73. Published 2018 Nov 21.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

 Chemical & Physical Properties

Molecular Formula C16H16D8N2O2
Molecular Weight 284.42300
Exact Mass 284.23400
PSA 45.33000
LogP 1.90070

 Synonyms

3-ethyl-2-methyl-5-[(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)methyl]-1,5,6,7-tetrahydroindol-4-one