TM5441
Modify Date: 2024-01-10 11:06:53
TM5441 structure
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Common Name | TM5441 | ||
|---|---|---|---|---|
| CAS Number | 1190221-43-2 | Molecular Weight | 428.829 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H17ClN2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TM5441TM5441 is a plasminogen activator inhibitor-1 (PAI-1); inhibits several tumor cell lines with IC50 values between 9.7 and 60.3 μM. |
| Name | TM5441 |
|---|---|
| Synonym | More Synonyms |
| Description | TM5441 is a plasminogen activator inhibitor-1 (PAI-1); inhibits several tumor cell lines with IC50 values between 9.7 and 60.3 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 9.7 and 60.3 μM (Tumor cell lines)[1] |
| In Vitro | TM5441 dose-dependently decreases HT1080, HCT116, Daoy, MDA-MB-231 and Jurkat cells with an IC50 ranging between 9.7 and 60.3 μM. TM5441 decreases tumor cell viability in part through diminished proliferation. TM5441 increases caspase 3/7 activity for both HT1080 and HCT116 cells in a dose dependant manner. TM5441is a potent stimulators of intrinsic apoptosis in tumor cells. TM5441 induces mitochondrial depolarization[1]. In mouse proximal tubular epithelial cells, TM5441 effectively inhibits PAI-1-induced mRNA expression of fibrosis and inflammation markers and also reverses PAI-1-induced inhibition of plasmin activity[2]. |
| In Vivo | Oral administration of TM5441 (20 mg/kg daily) to HT1080 and HCT116 xenotransplanted mice increases tumor cell apoptosis and has a significant disruptive effect on the tumor vasculature that is associated with a decrease in tumor growth and an increase in survival. The average peak plasma concentration is 11.4 μM one hour after oral administration and undetectable levels 23 hours after administration[1]. TM5441 effectively inhibits albuminuria, mesangial expansion, ECM accumulation, and macrophage infiltration in diabetic kidneys[2]. |
| Cell Assay | HT1080, HCT116, Daoy, MDA-MB-231 and Jurkat cells are treated with 0-100 μM TM5441 for 48 hours at 37°C. Cell viability is measured by MTT assay[1]. |
| Animal Admin | Mice: TM5275 at 50 mg/kg/day and TM5441 at 10 mg/kg/day were orally administered in control and diabetic mice for 16 weeks. Mice were monitored at least once a day. At the end, blood is collected for measurement of plasma glucose and creatinine, urine for protein measurement, and kidneys for immunohistochemical analysis[2]. |
| References |
| Molecular Formula | C21H17ClN2O6 |
|---|---|
| Molecular Weight | 428.829 |
| Storage condition | -20℃ |
| 5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoehtoxy)acetyl]amino)benzoic acid |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: TM5441
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: TM5441
- Price: $550.0/100mg $950.0/250mg $1900.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: TM5441
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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Price: $136/10mM*1mLinDMSO
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