IOWH032
Modify Date: 2024-01-06 19:21:09
IOWH032 structure
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Common Name | IOWH032 | ||
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| CAS Number | 1191252-49-9 | Molecular Weight | 545.180 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H15Br2N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IOWH032IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.IC50 value: 1.01 uM (CHO-CFTR FLIPR) [1]Target: CFTRProfiling of iOWH032 showed it to be a CFTR inhibitor in T84 and CHO-CFTR cell based assays. It also demonstrated statistical significant inhibition at both 100 g & 10 g doses in the mouse closed-loop model. iOWH032 was further profiled in a cecetomized rat model. iOWH032 reduced the fecal output index by ~70%, compared to vehicle (choleratoxin), up to 8 hours after a single 5 mg/kg po dose. |
| Name | 3-(3,5-dibromo-4-oxocyclohexa-2,5-dien-1-ylidene)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide |
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| Synonym | More Synonyms |
| Description | IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.IC50 value: 1.01 uM (CHO-CFTR FLIPR) [1]Target: CFTRProfiling of iOWH032 showed it to be a CFTR inhibitor in T84 and CHO-CFTR cell based assays. It also demonstrated statistical significant inhibition at both 100 g & 10 g doses in the mouse closed-loop model. iOWH032 was further profiled in a cecetomized rat model. iOWH032 reduced the fecal output index by ~70%, compared to vehicle (choleratoxin), up to 8 hours after a single 5 mg/kg po dose. |
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| Related Catalog | |
| References |
| Density | 1.7±0.1 g/cm3 |
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| Molecular Formula | C22H15Br2N3O4 |
| Molecular Weight | 545.180 |
| Exact Mass | 542.942932 |
| PSA | 97.22000 |
| LogP | 7.13 |
| Index of Refraction | 1.665 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
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| unii-8y3gdt6ywv |
| 1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]- |
| s7329 |
| 3-(3,5-Dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide |
| IOWH032 |
| IOWH-032 |
| iowh 032 |