Bisindolylmaleimide IV

Modify Date: 2024-01-02 15:12:37

Bisindolylmaleimide IV structure	Common Name	Bisindolylmaleimide IV
	CAS Number	119139-23-0	Molecular Weight	327.336
	Density	1.5±0.1 g/cm3	Boiling Point	690.1±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₃N₃O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	371.2±31.5 °C

Use of Bisindolylmaleimide IV

Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2].

Name	Bisindolylmaleimide IV
Synonym	More Synonyms

Description	Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Infection Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> CMV
Target	PKC:0.1-0.55 μM (IC50) HCMV:0.2 μM (IC50)
In Vitro	Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1].
References	[1]. Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. [2]. Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74.

Density	1.5±0.1 g/cm3
Boiling Point	690.1±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₃N₃O₂
Molecular Weight	327.336
Flash Point	371.2±31.5 °C
Exact Mass	327.100769
PSA	77.75000
LogP	3.21
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.811
Storage condition	-20℃

Bisindolylmaleimide IV MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2933990090

Precursor 10
CAS#:879-37-8 Indole-3-acetamide CAS#:18372-22-0 Methyl indolyl-... CAS#:3005-27-4 2,3-Dibromo-N-m... CAS#:7553-56-2 molecular iodine
CAS#:115684-57-6 3,4-bis(1H-indo... CAS#:342416-19-7 N-(2,4-dimethox... CAS#:22980-09-2 indole-3-glyoxy... CAS#:120-72-9 Indole
CAS#:113963-68-1 n-methylbis(ind... CAS#:1477-49-2 1H-Indol-3-yl(o...
DownStream 4
CAS#:133233-25-7 3,4-bis(1-methy... CAS#:113963-68-1 n-methylbis(ind... CAS#:133053-46-0 3-(1-methyl-3-i... CAS#:118458-54-1 Arcyriaflavin A

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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