TCO-NHS ester
TCO-NHS ester structure
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Common Name | TCO-NHS ester | ||
|---|---|---|---|---|
| CAS Number | 1191901-33-3 | Molecular Weight | 267.278 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 369.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C13H17NO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 177.0±28.7 °C | |
Use of TCO-NHS esterTCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione |
|---|---|
| Synonym | More Synonyms |
| Description | TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 369.1±45.0 °C at 760 mmHg |
| Molecular Formula | C13H17NO5 |
| Molecular Weight | 267.278 |
| Flash Point | 177.0±28.7 °C |
| Exact Mass | 267.110687 |
| LogP | 1.45 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.540 |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
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Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.
Bioconjug. Chem. 22 , 2263-2270, (2011) 1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa... |
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Tetrazine-based cycloadditions: application to pretargeted live cell imaging.
Bioconjug. Chem. 19 , 2297-2299, (2008) Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T... |
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Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.
J. Am. Chem. Soc. 130 , 13518-13519, (2008) Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol... |
| 1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione |
| 2,5-Pyrrolidinedione, 1-[[[(4Z)-4-cycloocten-1-yloxy]carbonyl]oxy]- |