Loureirin A

Modify Date: 2024-01-02 13:13:31

Use of Loureirin A

Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

Name	Loureirin A
Synonym	More Synonyms

Description	Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.
Related Catalog	Natural Products >> Flavonoids Research Areas >> Cardiovascular Disease
Target	Akt
In Vitro	Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1].
References	[1]. Hao HZ, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Eur J Pharmacol. 2015 Jan 5;746:63-9.

3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one

3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone

1-Propanone, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-

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Price: $198/10mM*1mLinDMSO

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