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Product Name: Tirandamycin A
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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: 2,4-Pyrrolidinedione,3-[(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]dec-8-yl]-2,4-heptadienylidene]-,(3E)- (9CI)
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34429-70-4

34429-70-4 structure

34429-70-4 structure

Name: Tirandamycin A
Chemical Name: Triandamycin
CAS Number: 34429-70-4
Molecular Formula: C₂₂H₂₇NO₇
Molecular Weight: 417.45200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-05-15 13:04:27
Modify Date: 2024-01-12 09:56:57
Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties[1][2].

Name	Triandamycin
Synonyms	TIRANDAMYCIN tirandamycin-A

Description	Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	A 60 μM treatment with Tirandamycin A results in a slightly stronger inhibition, demonstrating a 84.2% reduction in growth of Entamoeba histolytica HM-1:IMSS and 64.8% reduction in growth by Entamoeba histolytica Col. Tirandamycin A inhibits chain initiation and elongation of bacterial RNA polymerase without acting on mammalian polymerases[1].
References	[1]. Avelina Espinosa, et al. Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A. Parasitol Res. 2012 Dec;111(6):2473-7. [2]. H Hagenmaier, et al. Metabiolic products of microorganisms. Tirandamycin B(author's transl). Arch Microbiol. 1976 Aug;109(1-2):65-74.

Density	1.314g/cm3
Boiling Point	560.1ºC at 760mmHg
Molecular Formula	C₂₂H₂₇NO₇
Molecular Weight	417.45200
Flash Point	292.5ºC
Exact Mass	417.17900
PSA	114.46000
LogP	1.84130
Index of Refraction	1.577

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY7625500

CHEMICAL NAME :: 3-Pyrrolin-2-one, 4-hydroxy-3-(4-methyl-6-(1,2,7-trimethyl-5-oxo-3,9,10 - trioxatricyclo(4.3.1.0(sup 2,4))dec-8-yl)-2,4-heptadienoyl)-, (E,E)-

CAS REGISTRY NUMBER :: 34429-70-4

LAST UPDATED :: 198309

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H27-N-O7

MOLECULAR WEIGHT :: 417.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,69,1981