Eliprodil
Eliprodil structure
|
Common Name | Eliprodil | ||
|---|---|---|---|---|
| CAS Number | 119431-25-3 | Molecular Weight | 347.85400 | |
| Density | 1.205 g/cm3 | Boiling Point | 474.1ºC at 760 mmHg | |
| Molecular Formula | C20H23ClFNO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 240.5ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of EliprodilEliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).IC50 value:Target: NR2B-NMDA antagonistHuman N-type Ca2+ channel currents were inhibited by ifenprodil and eliprodil with IC50 values of 50 microM and 10 microM respectively whereas P-type Ca2+ channel currents were inhibited reversibly by ifenprodil and eliprodil with approximate IC50 values of 60 microM and 9 microM respectively. eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9). |
| Name | Eliprodil,α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).IC50 value:Target: NR2B-NMDA antagonistHuman N-type Ca2+ channel currents were inhibited by ifenprodil and eliprodil with IC50 values of 50 microM and 10 microM respectively whereas P-type Ca2+ channel currents were inhibited reversibly by ifenprodil and eliprodil with approximate IC50 values of 60 microM and 9 microM respectively. eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9). |
|---|---|
| Related Catalog | |
| References |
| Density | 1.205 g/cm3 |
|---|---|
| Boiling Point | 474.1ºC at 760 mmHg |
| Molecular Formula | C20H23ClFNO |
| Molecular Weight | 347.85400 |
| Flash Point | 240.5ºC |
| Exact Mass | 347.14500 |
| PSA | 23.47000 |
| LogP | 4.40510 |
| Vapour Pressure | 8.57E-10mmHg at 25°C |
| Index of Refraction | 1.58 |
| Storage condition | 2-8°C |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H410 |
| Precautionary Statements | P273-P305 + P351 + P338-P501 |
| Personal Protective Equipment | Eyeshields;Gloves |
| Hazard Codes | N: Dangerous for the environment; |
| Risk Phrases | R50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 9/PG 3 |
| HS Code | 2933399090 |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent.
Behav. Pharmacol. 12(2) , 143-9, (2001) Dopamine (DA) receptor blockade induces catalepsy in rats which increases in strength upon retesting. This increase in catalepsy represents a form of sensitization which has been shown to be completel... |
|
|
Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists.
Bioorg. Med. Chem. Lett. 10(12) , 1377-80, (2000) A short synthesis of the NMDA receptor antagonist (rac)-Eliprodil (9) and its resolution into the enantiomers by chiral HPLC is described. The enantiomers (R)-9 and (S)-9 were found to exhibit markedl... |
|
|
The sequential analysis of repeated binary responses: a score test for the case of three time points.
Stat. Med. 25(13) , 2196-214, (2006) In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compa... |
| eliprodil |