NCX 470

Modify Date: 2024-01-06 12:58:31

NCX 470 Structure
NCX 470 structure
Common Name NCX 470
CAS Number 1194396-71-8 Molecular Weight 574.71
Density N/A Boiling Point N/A
Molecular Formula C31H46N2O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NCX 470


NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. NCX 470 can be used for the research of cular hypertension and glaucoma[1][2].

 Names

Name Hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester

 NCX 470 Biological Activity

Description NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. NCX 470 can be used for the research of cular hypertension and glaucoma[1][2].
Related Catalog
In Vivo NCX 470 shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension[1]. NCX 470 (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits[2]. NCX 470 (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in ONT-dogs and in OHT-monkeys at 18 hours post dosing[2]. Animal Model: New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injection[2] Dosage: 0.14% Administration: Instillation; 0.14% 30 μL; once Result: Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.

 Chemical & Physical Properties

Molecular Formula C31H46N2O8
Molecular Weight 574.71