12-Ethyl-9-hydroxycamptothecin

Modify Date: 2024-01-05 23:13:25

12-Ethyl-9-hydroxycamptothecin Structure
12-Ethyl-9-hydroxycamptothecin structure
 Common Name 12-Ethyl-9-hydroxycamptothecin
CAS Number 119577-28-5 Molecular Weight 392.40
Density 1.5±0.1 g/cm3 Boiling Point 810.3±65.0 °C at 760 mmHg
Molecular Formula C22H20N2O5 Melting Point N/A
MSDS N/A Flash Point 443.8±34.3 °C

 Use of 12-Ethyl-9-hydroxycamptothecin


12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].

 Names

Name 7-ethyl-10-hydroxycamptothecin
Synonym More Synonyms

 12-Ethyl-9-hydroxycamptothecin Biological Activity

Description 12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].
Related Catalog
In Vitro 12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin.
References

[1]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995;38(3):395-401.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 810.3±65.0 °C at 760 mmHg
Molecular Formula C22H20N2O5
Molecular Weight 392.40
Flash Point 443.8±34.3 °C
Exact Mass 392.137207
PSA 101.65000
LogP 2.31
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.738
Storage condition 2-8C

 Safety Information

HS Code 2942000000

 Customs

HS Code 2942000000

 Synonyms

(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
SN-38
SN38
7-Ethyl-10-hydroxycamptothecine
(4S)-4,11-DIETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7] INDOLIZINO [1,2-B] QUINOLINE-3,14 (4H,12H)-DIONE
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