MK-1064
Modify Date: 2024-01-10 17:40:38
MK-1064 structure
|
Common Name | MK-1064 | ||
|---|---|---|---|---|
| CAS Number | 1207253-08-4 | Molecular Weight | 461.900 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 662.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C24H20ClN5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 354.4±31.5 °C | |
Use of MK-1064MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.target: 2-SORA [1]In vivo: MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg/kg. [2] |
| Name | 5''-Chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.target: 2-SORA [1]In vivo: MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg/kg. [2] |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 662.4±55.0 °C at 760 mmHg |
| Molecular Formula | C24H20ClN5O3 |
| Molecular Weight | 461.900 |
| Flash Point | 354.4±31.5 °C |
| Exact Mass | 461.125458 |
| LogP | 3.04 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.619 |
| Storage condition | 2-8℃ |
| [2,2':5',3''-Terpyridine]-3'-carboxamide, 5''-chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]- |
| 5''-Chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide |
| MFCD28502027 |
| MK-1064 |