BMN-673 (8R,9S)

Modify Date: 2024-01-02 10:30:22

BMN-673 (8R,9S) Structure
BMN-673 (8R,9S) structure
 Common Name BMN-673 (8R,9S)
CAS Number 1207456-00-5 Molecular Weight 380.35100
Density N/A Boiling Point N/A
Molecular Formula C19H14F2N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BMN-673 (8R,9S)


Talazoparib 8R,9S (BMN-673 8R,9S) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC50 of 144 nM.

 Names

Name (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one
Synonym More Synonyms

 BMN-673 (8R,9S) Biological Activity

Description Talazoparib 8R,9S (BMN-673 8R,9S) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC50 of 144 nM.
Related Catalog
Target

PARP-1:144 nM (IC50)

References

[1]. Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-

 Chemical & Physical Properties

Molecular Formula C19H14F2N6O
Molecular Weight 380.35100
Exact Mass 380.12000
PSA 91.98000
LogP 1.89830

 Synthetic Route

 Synonyms

(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
BMN-673 8R,9S||BMN673 (8R,9S)|BMN 673 (8R,9S)
BMN 673 (8R,9S)
CS-1223
BMN-673 (8R,9S)
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