1207456-00-5

1207456-00-5 structure

Name: BMN-673 (8R,9S)
Chemical Name: (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one
CAS Number: 1207456-00-5
Molecular Formula: C₁₉H₁₄F₂N₆O
Molecular Weight: 380.35100
Catalog: Research Areas Cancer
Create Date: 2017-06-15 05:06:59
Modify Date: 2024-01-02 10:30:22
Talazoparib 8R,9S (BMN-673 8R,9S) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC50 of 144 nM.

Name	(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one
Synonyms	(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one BMN-673 8R,9S\|\|BMN673 (8R,9S)\|BMN 673 (8R,9S) BMN 673 (8R,9S) CS-1223 BMN-673 (8R,9S)

Description	Talazoparib 8R,9S (BMN-673 8R,9S) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC50 of 144 nM.
Related Catalog	Research Areas >> Cancer
Target	PARP-1:144 nM (IC50)
References	[1]. Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-