Sorafenib-d4

Modify Date: 2024-01-05 11:55:04

Sorafenib-d4 Structure
Sorafenib-d4 structure
Common Name Sorafenib-d4
CAS Number 1207560-07-3 Molecular Weight 468.85
Density N/A Boiling Point N/A
Molecular Formula C21H12D4ClF3N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Sorafenib-d4


Sorafenib D4 (Bay 43-9006 D4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

 Names

Name Sorafenib (D4)

 Sorafenib-d4 Biological Activity

Description Sorafenib D4 (Bay 43-9006 D4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
Related Catalog
References

[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

 Chemical & Physical Properties

Molecular Formula C21H12D4ClF3N4O3
Molecular Weight 468.85