Riluzole-13C,15N2

Modify Date: 2024-01-02 16:32:13

Riluzole-13C,15N2 Structure
Riluzole-13C,15N2 structure
Common Name Riluzole-13C,15N2
CAS Number 1215552-03-6 Molecular Weight 237.2253096
Density N/A Boiling Point N/A
Molecular Formula C8H5F3N2OS Melting Point 113-116°C
MSDS N/A Flash Point N/A

 Use of Riluzole-13C,15N2


Riluzole-13C,15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].

 Names

Name RILUZOLE-13C,15N2

 Riluzole-13C,15N2 Biological Activity

Description Riluzole-13C,15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 2002 Feb;42(2):199-209.  

[3]. Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 2811:51.  

 Chemical & Physical Properties

Melting Point 113-116°C
Molecular Formula C8H5F3N2OS
Molecular Weight 237.2253096
Storage condition Refrigerator