Pancopride
Modify Date: 2024-01-10 10:36:57
Pancopride structure
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Common Name | Pancopride | ||
|---|---|---|---|---|
| CAS Number | 121650-80-4 | Molecular Weight | 349.85500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H24ClN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PancopridePancopride is a new potent and selective 5-HT3 receptor antagonist. |
| Name | 4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-(cyclopropylmethoxy)benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | Pancopride is a new potent and selective 5-HT3 receptor antagonist. |
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| Related Catalog | |
| Target |
5-HT3 receptor[1] |
| In Vitro | Pancopride is a new potent and selective 5-HT3 receptor antagonist, orally and parenterally effective against cytotoxic drug-induced emesis. Pancopride displayed high affinity (Ki=0.40 nM) for [3H]GR65630-labelled 5-HT3 recognition sites in membranes from the cortex of rat brains[1]. |
| In Vivo | Pancopride antagonizes 5-HT-induced bradycardia in anaesthetized rats when administered i.v. 5 min (ID50=0.56 μg/kg) or p.o. 60 min (ID50=8.7 μg/kg) before 5-HT challenge. A single oral dose (10 μg/kg) of Pancopride produced a significant inhibition of the bradycardic reflex over an 8-h period. Pancopride dose dependently inhibited the number of vomiting episodes and delayed the onset of vomiting induced by cisplatin in dogs (ID50=3.6 μg/kg i.v. and 7.1 μg/kg p.o.)[1]. Pancopride inhibits vomiting induced by cisplatin in dogs and is also effective in blocking mechloretamine- and dacarbazine-induced emesis lacking any antidopaminergic activity. Pancopride stimulates gastric emptying of glass beads in the rat (DE50=0.032 mg/kg p.o.). Pancopride (1 mg/kg i.p.) also reverses cisplatin induced slowing of gastric emptying in the rat[2]. |
| References |
| Molecular Formula | C18H24ClN3O2 |
|---|---|
| Molecular Weight | 349.85500 |
| Exact Mass | 349.15600 |
| PSA | 67.59000 |
| LogP | 3.44500 |
| Storage condition | 2-8℃ |
| Pancopride |
| N-(1-azabicyclo[2.2.2]oct-3-yl)-2-cyclopropylmethoxy-4-amino-5-chlorobenzamide |
| pancopride |