(rac)-Nebivolol-d8

Modify Date: 2024-01-09 17:32:54

(rac)-Nebivolol-d8 structure	Common Name	(rac)-Nebivolol-d8
	CAS Number	1219166-00-3	Molecular Weight	413.48400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₇D₈F₂NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (rac)-Nebivolol-d8

(Rac)-Nebivolol-d8 ((rac)-R 065824-d8) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].

Name	rac Nebivolol-d8
Synonym	More Synonyms

Description	(Rac)-Nebivolol-d8 ((rac)-R 065824-d8) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49(2):430-9. [3]. Mercanoglu G, et al. The effects of nebivolol on apoptosis in a rat infarct model. Circ J. 2008 Apr;72(4):660-70.

Molecular Formula	C₂₂H₁₇D₈F₂NO₄
Molecular Weight	413.48400
Exact Mass	413.22500
PSA	70.95000
LogP	2.75450

2-[[2-hydroxy-2-(3,3,4,4-tetradeuterio-6-fluoro-2H-chromen-2-yl)ethyl]amino]-1-(3,3,4,4-tetradeuterio-6-fluoro-2H-chromen-2-yl)ethanol

(rac)-Nebivolol-d8

Use of (rac)-Nebivolol-d8

Names

(rac)-Nebivolol-d8 Biological Activity

Chemical & Physical Properties

Synonyms