Loracarbef hydrate

Modify Date: 2024-01-05 07:23:17

Loracarbef hydrate Structure
Loracarbef hydrate structure
Common Name Loracarbef hydrate
CAS Number 121961-22-6 Molecular Weight 367.78400
Density N/A Boiling Point 662.2ºC at 760 mmHg
Molecular Formula C16H18ClN3O5 Melting Point 205-215° (dec) (Matsukuma)
MSDS N/A Flash Point 354.3ºC

 Use of Loracarbef hydrate


Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class[1][2].

 Names

Name loracarbef (200 mg)
Synonym More Synonyms

 Loracarbef hydrate Biological Activity

Description Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class[1][2].
Related Catalog
In Vitro Loracarbef hydrate demonstrates excellent activity against isolates of Escherichia coli and Klebsiella, Proteus and Salmonella species[2].
References

[1]. M Hu, et al. Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison With Cephalexin. Pharm Res. 1995 Aug;12(8):1120-5.

[2]. J W Dyke, et al. Antimicrobial Activity of New Antibiotics Against Bacterial Isolates From a Community Hospital. Chemotherapy. Sep-Oct 1993;39(5):315-21.

 Chemical & Physical Properties

Boiling Point 662.2ºC at 760 mmHg
Melting Point 205-215° (dec) (Matsukuma)
Molecular Formula C16H18ClN3O5
Molecular Weight 367.78400
Flash Point 354.3ºC
Exact Mass 367.09300
PSA 121.96000
LogP 1.67560
Vapour Pressure 1.95E-18mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL6175600
CHEMICAL NAME :
1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, monohydrate, (6R-(6-alpha,7-beta(R*)))-
CAS REGISTRY NUMBER :
121961-22-6
LAST UPDATED :
199506
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H16-Cl-N3-O4.H2-O
MOLECULAR WEIGHT :
367.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 43,60,1993

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

1-Azabicyclo4.2.0oct-2-ene-2-carboxylic acid,7-(2R)-aminophenylacetylamino-3-chloro-8-oxo-,monohydrate,(6R,7S)
kt3777
Carbacefaclor
7-((aminophenylacetyl)amino)-3-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicaci
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