BMS-933043

Modify Date: 2024-09-15 18:21:07

BMS-933043 Structure
BMS-933043 structure
Common Name BMS-933043
CAS Number 1221973-93-8 Molecular Weight 325.368
Density 1.6±0.1 g/cm3 Boiling Point 539.3±60.0 °C at 760 mmHg
Molecular Formula C16H19N7O Melting Point N/A
MSDS N/A Flash Point 279.9±32.9 °C

 Use of BMS-933043


BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition. Schizophrenia Phase 1 Discontinued

 Names

Name N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine
Synonym More Synonyms

 BMS-933043 Biological Activity

Description BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition. Schizophrenia Phase 1 Discontinued
References References 1. King D, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. 2. Bristow LJ, et al. PLoS One. 2016 Jul 28;11(7):e0159996. 3. Weed MR, et al. PLoS One. 2017 Dec 19;12(12):e0187609. View Related Products by Target nAChR Schizophrenia

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 539.3±60.0 °C at 760 mmHg
Molecular Formula C16H19N7O
Molecular Weight 325.368
Flash Point 279.9±32.9 °C
Exact Mass 325.165100
LogP 0.27
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.815

 Synonyms

Spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine, N-[6-(1H-imidazol-1-yl)-4-pyrimidinyl]-
N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine
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