1221973-93-8

1221973-93-8 structure

Name: BMS-933043
Chemical Name: N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine
CAS Number: 1221973-93-8
Molecular Formula: C₁₆H₁₉N₇O
Molecular Weight: 325.368
Create Date: 2020-01-12 08:30:51
Modify Date: 2024-09-15 18:21:07
BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition. Schizophrenia Phase 1 Discontinued

Name	N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine
Synonyms	Spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine, N-[6-(1H-imidazol-1-yl)-4-pyrimidinyl]- N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine

Description	BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition. Schizophrenia Phase 1 Discontinued
References	References 1. King D, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. 2. Bristow LJ, et al. PLoS One. 2016 Jul 28;11(7):e0159996. 3. Weed MR, et al. PLoS One. 2017 Dec 19;12(12):e0187609. View Related Products by Target nAChR Schizophrenia