Tyrphostin 51

Modify Date: 2024-01-21 11:52:28

Tyrphostin 51 structure	Common Name	Tyrphostin 51
	CAS Number	122520-90-5	Molecular Weight	268.228
	Density	1.6±0.1 g/cm3	Boiling Point	788.2±60.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₈N₄O₃	Melting Point	278ºC
	MSDS	Chinese	Flash Point	430.5±32.9 °C

Use of Tyrphostin 51

(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].

Name	tyrphostin a51
Synonym	More Synonyms

Description	(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> EGFR Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230. [2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9.

Description

Related Catalog

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Research Areas >> Others

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

References

[1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230.

[2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9.

Density	1.6±0.1 g/cm3
Boiling Point	788.2±60.0 °C at 760 mmHg
Melting Point	278ºC
Molecular Formula	C₁₃H₈N₄O₃
Molecular Weight	268.228
Flash Point	430.5±32.9 °C
Exact Mass	268.059631
PSA	158.08000
LogP	0.04
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.757
Storage condition	2-8°C

WGK Germany	3

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)-

ag 183

tyrphostin ag 183

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-

tyrphostin 51

(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile

(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile

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China
Product Name: AG-183
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DC Chemicals Limited
China
Product Name: AG-183
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