![]() gn25 structure
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Common Name | gn25 | ||
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CAS Number | 1227401-27-5 | Molecular Weight | 322.333 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 608.4±55.0 °C at 760 mmHg | |
Molecular Formula | C15H14O6S | Melting Point | N/A | |
MSDS | N/A | Flash Point | 321.7±31.5 °C |
Use of gn25GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1]. |
Name | gn25 |
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Synonym | More Synonyms |
Description | GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1]. |
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Related Catalog | |
In Vitro | GN25 (10 and 20 μM; 24 h) inhibits cell viability of K-Ras-mutated MEF cells[1]. GN25 (5 μM; 4 h) activates p53 in a K-Ras-dependent manner[1]. GN25 (1-10 μM; 1-6 h) induces p53 and p21 in a dose- and time- dependent manner in K-Ras-mutated A549 and HCT116 cell lines[1]. GN25 activates wild-type p53 in p53WT/MT cells[1]. GN25 (0.25 μM) recovers the masking effect of p53 on CK1/GSK3b-mediated Snail phosphorylation[1]. Cell Viability Assay[1] Cell Line: HCT116, A459 and MKN45 cell lines Concentration: 10 μM Incubation Time: 24 h Result: Obviously suppressed the cell viability of HCT116 and A459 cell lines. Cell Proliferation Assay[1] Cell Line: K-Ras-transformed and N-Ras/Myc-transformed MEF cells Concentration: 10 μM and 20 μM Incubation Time: 24 h Result: Inhibited the viability of K-Ras-transformed but not N-Ras/Myc-transformed MEF cells. Western Blot Analysis[1] Cell Line: K-Ras-MEF, N-Ras/Myc-MEF and Nontransformed MEF cells Concentration: 5 μM Incubation Time: 4 h Result: Only induced p53 and p21 in K-Ras-MEF cells. Western Blot Analysis[1] Cell Line: K-Ras-mutated A549, HCT116 cell lines and MKN45 Concentration: 1, 5, and 10 μM Incubation Time: 1, 3, and 6 h Result: Induced p53 and p21 in a dose- and time- dependent manner in A549 and HCT116 cells. |
In Vivo | GN25 (10 and 20 mg/kg; i.p. once a week for 10 weeks) blocks the tumor progression and induces tumor regression in mice[1]. Animal Model: Athymic mice with A549 xenografts[1] Dosage: 10 and 20 mg/kg Administration: Intraperitoneal injection; once a week for 10 weeks Result: Obviously regressed tumors in mice. Showed no significant toxicity in liver, pancreas and kidney. |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 608.4±55.0 °C at 760 mmHg |
Molecular Formula | C15H14O6S |
Molecular Weight | 322.333 |
Flash Point | 321.7±31.5 °C |
Exact Mass | 322.051117 |
PSA | 115.20000 |
LogP | 2.19 |
Vapour Pressure | 0.0±1.8 mmHg at 25°C |
Index of Refraction | 1.622 |
Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]- |
3-[(5,8-Dimethoxy-1,4-dioxo-1,4-dihydro-2-naphthalenyl)sulfanyl]propanoic acid |
1H-Indole-3-propanal,5,7-difluoro |