Balovaptan

Modify Date: 2024-01-10 18:39:03

Balovaptan Structure
Balovaptan structure
Common Name Balovaptan
CAS Number 1228088-30-9 Molecular Weight 409.912
Density 1.4±0.1 g/cm3 Boiling Point 597.0±60.0 °C at 760 mmHg
Molecular Formula C22H24ClN5O Melting Point N/A
MSDS N/A Flash Point 314.9±32.9 °C

 Use of Balovaptan


Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

 Names

Name balovaptan
Synonym More Synonyms

 Balovaptan Biological Activity

Description Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
Related Catalog
Target

Ki: 1 nM (hV1a), 39 nM (mV1a)[1]

In Vitro Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for hV1a and mhV1a, and is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].
References

[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 597.0±60.0 °C at 760 mmHg
Molecular Formula C22H24ClN5O
Molecular Weight 409.912
Flash Point 314.9±32.9 °C
Exact Mass 409.166931
LogP 3.16
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.702

 Synonyms

4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-5,6-dihydro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-
RAX5D5AGV6
8-Chloro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
10298
balovaptan