Phyltetralin

Modify Date: 2024-01-10 11:36:09

Phyltetralin Structure
Phyltetralin structure
Common Name Phyltetralin
CAS Number 123048-17-9 Molecular Weight 416.51
Density N/A Boiling Point N/A
Molecular Formula C24H32O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Phyltetralin


Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system[1][2].

 Names

Name (+)-phyltetralin
Synonym More Synonyms

 Phyltetralin Biological Activity

Description Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system[1][2].
Related Catalog
In Vitro Phyltetralin shows inhibition on Polymorphonuclear neutrophil (PMN) chemotaxis with an IC50 of 4.01 µM[2]. Phyltetralin shows strong inhibition against reactive oxygen species (ROS) production from PMA-stimulated neutrophil with an IC50 of 0.73 µM[2]. Phyltetralin shows weak inhibition on CD18 expression and moderate inhibition on engulfment activity[2].
References

[1]. Conrado GG, et al. Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity. Planta Med. 2020 Jul;86(11):782-789.

[2]. Yuandani, et al. 1, 7, 8-trihydroxy 2-naphtaldehyde, ethyl 8-hydroxy-8-methyl-tridecanoate and 1-triacontanol from Phyllanthus amarus Schumach. & Thonn. inhibit phagocytic activity of human leucocytes[J]. Journal of Pharmacy and Pharmacology, 2019, 71(9): 1451-1457.

 Chemical & Physical Properties

Molecular Formula C24H32O6
Molecular Weight 416.51
Exact Mass 416.22000
PSA 55.38000
LogP 3.93420

 Synonyms

phyltetralin
(1R,2S,3S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-2,3-bis-methoxymethyl-1,2,3,4-tetrahydro-naphthalene
Phyltetralin