LY2828360
Modify Date: 2024-01-05 13:11:47
LY2828360 structure
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Common Name | LY2828360 | ||
|---|---|---|---|---|
| CAS Number | 1231220-79-3 | Molecular Weight | 426.942 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 541.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C22H27ClN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 281.5±32.9 °C | |
Use of LY2828360LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling. |
| Name | Ly-2828360 |
|---|---|
| Synonym | More Synonyms |
| Description | LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling. |
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| Related Catalog | |
| Target |
CB2[1]. |
| In Vivo | In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical and cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical and cold hypersensitivities and suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB2KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical and cold allodynia in WT mice but not in CB2KO mice previously render tolerant to morphine[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 541.8±60.0 °C at 760 mmHg |
| Molecular Formula | C22H27ClN6O |
| Molecular Weight | 426.942 |
| Flash Point | 281.5±32.9 °C |
| Exact Mass | 426.193481 |
| LogP | 1.60 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.701 |
| Storage condition | 2-8℃ |
| 9H-Purine, 8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)- |
| Ly-2828360 |
| 8-(2-Chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine |