()-trans-C75

Modify Date: 2024-01-04 19:14:20

()-trans-C75 structure	Common Name	()-trans-C75
	CAS Number	1234694-22-4	Molecular Weight	254.32
	Density	1.1±0.1 g/cm3	Boiling Point	432.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₂₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	159.2±22.2 °C

Use of ()-trans-C75

(−)-C75 is a isoform of C75 (HY-12364), which is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5].

Name	(-)-trans-C75
Synonym	More Synonyms

Description	(−)-C75 is a isoform of C75 (HY-12364), which is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
References	[1]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560. [2]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. [3]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [4]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33. [5]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)

References

[1]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560.

[2]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.

[3]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.

[4]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

[5]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

Density	1.1±0.1 g/cm3
Boiling Point	432.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₂₂O₄
Molecular Weight	254.32
Flash Point	159.2±22.2 °C
Exact Mass	254.151810
PSA	63.60000
LogP	3.65
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.489

(2S,3R)-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

(2S,3R)-4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

(2S,3R)-4-Methylene-2-octyl-5-oxotetrahydro-3-furancarboxylic acid

3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2S,3R)-

()-trans-C75

Use of ()-trans-C75

Names

()-trans-C75 Biological Activity

Chemical & Physical Properties

Synonyms