Adipic acid

Modify Date: 2024-01-02 00:06:15

Adipic acid Structure
Adipic acid structure
 Common Name Adipic acid
CAS Number 124-04-9 Molecular Weight 146.141
Density 1.3±0.1 g/cm3 Boiling Point 338.5±15.0 °C at 760 mmHg
Molecular Formula C6H10O4 Melting Point 151-154 °C(lit.)
MSDS Chinese USA Flash Point 196 ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Adipic acid


Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

 Names

Name Adipic acid
Synonym More Synonyms

 Adipic acid Biological Activity

Description Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center. METAGENE consortium.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 338.5±15.0 °C at 760 mmHg
Melting Point 151-154 °C(lit.)
Molecular Formula C6H10O4
Molecular Weight 146.141
Flash Point 196 ºC
Exact Mass 146.057907
PSA 74.60000
LogP 0.08
Vapour density 5 (vs air)
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.476
Stability Stable. Substances to be avoided include ammonia, strong oxidizing agents.
Water Solubility 1.44 g/100 mL (15 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU8400000
CHEMICAL NAME :
Adipic acid
CAS REGISTRY NUMBER :
124-04-9
BEILSTEIN REFERENCE NO. :
1209788
LAST UPDATED :
199712
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C6-H10-O4
MOLECULAR WEIGHT :
146.16
WISWESSER LINE NOTATION :
QV4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,315,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(9),72,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
275 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Blood - hemorrhage
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 5,759,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 5,759,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Blood - hemorrhage
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 5,759,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(9),72,1983 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 4 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84427 No. of Facilities: 1068 (estimated) No. of Industries: 21 No. of Occupations: 42 No. of Employees: 14846 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84427 No. of Facilities: 6259 (estimated) No. of Industries: 54 No. of Occupations: 66 No. of Employees: 140635 (estimated) No. of Female Employees: 77996 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36
Safety Phrases S26
RIDADR UN 9077
WGK Germany 1
RTECS AU8400000
Hazard Class 9.2
HS Code 2917120001

 Synthetic Route

 Customs

HS Code 2917120001
Summary HS: 2917120001 adipic acid Tax rebate rate:13.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

 Articles59

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 Synonyms

Acifloctin
1,6-Hexanedioic acid
Adilactetten
1,4-Butanedicarboxylic acid
EINECS 204-673-3
hexane-1,6-dicarboxylic acid
hexanedioic acid
Acinetten
Adipic acid
MFCD00004420
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