SN-32976
Modify Date: 2024-01-20 11:39:22
SN-32976 structure
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Common Name | SN-32976 | ||
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| CAS Number | 1246202-11-8 | Molecular Weight | 581.638 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 760.7±70.0 °C at 760 mmHg | |
| Molecular Formula | C24H33F2N9O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 413.8±35.7 °C | |
Use of SN-32976SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively; displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases; inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models. |
| Name | 2-[(4-{4-[2-(Difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl}-1-piperazinyl)sulfonyl]-N,N-dimethylethanamine |
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| Synonym | More Synonyms |
| Description | SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively; displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases; inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models. |
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| References | References 1. Rewcastle GW, et al. Oncotarget. 2017 May 9. doi: 10.18632/oncotarget.17730. View Related Products by Target PI3K |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 760.7±70.0 °C at 760 mmHg |
| Molecular Formula | C24H33F2N9O4S |
| Molecular Weight | 581.638 |
| Flash Point | 413.8±35.7 °C |
| Exact Mass | 581.234436 |
| LogP | -0.20 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.672 |
| 2-[(4-{4-[2-(Difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl}-1-piperazinyl)sulfonyl]-N,N-dimethylethanamine |
| Ethanamine, 2-[[4-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-1-piperazinyl]sulfonyl]-N,N-dimethyl- |