823218-99-1
823218-99-1 structure
- Name: SN 2
- Chemical Name: SN 2
- CAS Number: 823218-99-1
- Molecular Formula: C17H21NO
- Molecular Weight: 255.355
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2018-05-04 12:15:04
- Modify Date: 2024-01-02 23:09:38
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SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.
| Name | SN 2 |
|---|---|
| Synonyms |
5-Mesityl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
4,7-Methano-1,2-benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(2,4,6-trimethylphenyl)- MFCD05739166 MFCD09266779 |
| Description | SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM. |
|---|---|
| Related Catalog | |
| Target |
EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1] |
| In Vitro | The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1]. |
| References |
[1]. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 370.8±52.0 °C at 760 mmHg |
| Molecular Formula | C17H21NO |
| Molecular Weight | 255.355 |
| Flash Point | 144.5±23.2 °C |
| Exact Mass | 255.162308 |
| LogP | 4.25 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.665 |
| Storage condition | 2-8℃ |