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  • DC Chemicals Limited
  • China
  • Product Name: SN 2
  • Price: $500.0/100mg $1000.0/250mg $2000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

823218-99-1

823218-99-1 structure
823218-99-1 structure
  • Name: SN 2
  • Chemical Name: SN 2
  • CAS Number: 823218-99-1
  • Molecular Formula: C17H21NO
  • Molecular Weight: 255.355
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
  • Create Date: 2018-05-04 12:15:04
  • Modify Date: 2024-01-02 23:09:38
  • SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.

Name SN 2
Synonyms 5-Mesityl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
4,7-Methano-1,2-benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(2,4,6-trimethylphenyl)-
MFCD05739166
MFCD09266779
Description SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.
Related Catalog
Target

EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]

In Vitro The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1].
References

[1]. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.

Density 1.3±0.1 g/cm3
Boiling Point 370.8±52.0 °C at 760 mmHg
Molecular Formula C17H21NO
Molecular Weight 255.355
Flash Point 144.5±23.2 °C
Exact Mass 255.162308
LogP 4.25
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.665
Storage condition 2-8℃