Tizoxanide-d4

Modify Date: 2024-01-02 16:29:49

Tizoxanide-d4 structure	Common Name	Tizoxanide-d4
	CAS Number	1246817-56-0	Molecular Weight	269.270
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₃D₄N₃O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tizoxanide-d4

Tizoxanide D4 (TIZ D4) is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].

Name	Tizoxanide-d4
Synonym	More Synonyms

Description	Tizoxanide D4 (TIZ D4) is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Korba BE, et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008 Jan;77(1):56-63. [3]. Ashton LV, et al. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet Med Int. 2010 Aug 12;2010. pii: 891010. [4]. Korba BE, et al. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob Agents Chemother. 2008 Nov;52(11):4069-71. [5]. Trabattoni D, et al. Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication. Sci Rep. 2016 Jun 2;6:27148.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₀H₃D₄N₃O₄S
Molecular Weight	269.270
Exact Mass	269.040833
LogP	2.91
Index of Refraction	1.750

2-Hydroxy-N-(5-nitro-1,3-thiazol-2-yl)(2H4)benzamide

Benzamide-2,3,4,5-d4, 6-hydroxy-N-(5-nitro-2-thiazolyl)-

Tizoxanide-d4

Tizoxanide-d4

Use of Tizoxanide-d4

Names

Tizoxanide-d4 Biological Activity

Chemical & Physical Properties

Synonyms