Pyridoxal phosphate-d5

Modify Date: 2024-01-07 22:26:03

Pyridoxal phosphate-d5 structure	Common Name	Pyridoxal phosphate-d5
	CAS Number	1246818-16-5	Molecular Weight	252.17
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈H₅D₅NO₆P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pyridoxal phosphate-d5

Pyridoxal phosphate-d5 (Pyridoxal 5′-phosphate-d5) is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].

Name	Pyridoxal phosphate-d5

Description	Pyridoxal phosphate-d5 (Pyridoxal 5′-phosphate-d5) is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Reverse Transcriptase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. [3]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.

Molecular Formula	C₈H₅D₅NO₆P
Molecular Weight	252.17

Pyridoxal phosphate-d5

Use of Pyridoxal phosphate-d5

Names

Pyridoxal phosphate-d5 Biological Activity

Chemical & Physical Properties